Yes, the infamous worms!
I have never been a true pixel peeper, but an image has to look as sharp (or not so sharp) as I see it in my head--and be able to print accordingly. I did not find noise and artifacts to be a significant issue with my Nikon D7100 unless shooting at higher ISO numbers--yet I wanted more detail and printable size, but not with bugs...
It was a real voyage to the land of Fuji. Loved the images I saw, how the camera body was configured--and best of all with a Fringer adapter could use the entire stable of Nikkor DX lenses I already owned. My own folly for not researching what was necessary in post to achieve those great photos I saw...
The trouble I soon discovered is the proprietary method that Fuji uses with the X-Trans sensor and the creation of RAF files. It is surprising that in an Adobe workflow (RAW converter + Photoshop) versus image import, simple JPG's appeared crisper and with better contrast and saturation than processed RAF's as a PSD. From that format, I have always created JPG/PNG files for digital display and the PSD for printing. I have never liked Lightroom due to the XMP sidecar files. God help you if that file is lost, or one decides to move both files to another folder.
I have the worms and pixelation appearing at about 200% on every image taken in directly through the RAW filter to PS. Adding sharpening simply introduces harsh 'grain globs' and highlights the worms. Not what I spent $2500 to achieve...
My first experiment here is going to be with the AI-driven 'denoise' function of the PS RAW filter, and conversion into a DNG format. The images I have tinkered with so far are a giant leap forward from where I started and exceed what I had before with the Nikon NEF files. Then, I will try Capture One, which I seem to be having a bit of trouble getting my head around! Results will be posted.
Then I just downloaded a new bobby-dazzler, Fujifilm X Raw Studio. This is seeming a bit like conventional darkroom practice, in choosing what to develop one's film in!